منابع مشابه
Anti-phospholipid/Cofactor Antibodies
Following a meeting at Sapporo, Japan, an international consensus statement on preliminary classification criteria for definite anti-phospholipid syndrome was published.1 This set of criteria is divided into the clinical part which includes vascular thrombosis and pregnancy morbidity and the laboratory part which includes anti-cardiolipin (aCL) antibody and lupus anti-coagulant tests. Diagnosis...
متن کاملAnti-phospholipid antibodies and pregnancy
The presence of antiphospholipid antibodies is linked to an increased rate of repeated spontaneous abortions and fetal deaths, that in fact belong to the clinical spectrum of the antiphospholipid syndrome. The pathogenic role of antiphospholipid antibodies was clearly shown in experimental animals that, when infused during pregnancy, develop placental insufficiency and miscarriages. In addition...
متن کاملAnti-phospholipid Antibodies and Thrombosis
The paper gives some preliminary comments on the submissions to Discovery Challenge on Thrombosis data.
متن کامل[Pathogenic mechanisms of the anti-phospholipid antibodies].
The antiphospolipid syndrome (APS) is an autoimmune disease characterized by recurrent fetal loss, thrombotic events (arterial or venous) and hemocytopenic disorders associated to high titers of circulating aPL. Two variants of the APS have been described. Primary APS is a clinical entity without evidence of any other autoimmune disease and secondary APS is a clinical disorder mainly associated...
متن کاملSulfatides: targets for anti-phospholipid antibodies.
BACKGROUND Sulfatides are sulfated glycosphingolipids expressed on the surface of erythrocytes, leukocytes, and platelets. Sulfatides interact with several cell adhesion molecules involved in hemostasis. Beta2-glycoprotein I is an anionic phospholipid-binding plasma protein, and the phospholipid-bound form is the target for most anti-phospholipid antibodies that are associated with recurrent th...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2013
ISSN: 1462-0324,1462-0332
DOI: 10.1093/rheumatology/ket394